A study by researchers from the University of Queensland has found that amyloid plaque in the brain – which is associated with Alzheimer’s disease – doesn’t need to be specifically targeted prior to ultrasound therapy for ultrasound to be effective in providing cognitive improvements in neurodegenerative disorders.
Previously amyloid has been targeted with microbubbles, which open the blood-brain barrier and activate microglia cells which clear amyloid plaque. However, in this study, which was published in Molecular Psychiatry, ultrasound was used in isolation on mice and significant memory enhancement was observed.
You can read more here: https://www.uq.edu.au/news/article/2024/04/ultrasound-therapy-shows-promise-treatment-alzheimer’s-disease and access the full research paper in Molecular Psychiatry here https://www.nature.com/articles/s41380-024-02509-5.